A case report of cornelia de lange syndrome in Northern Iran; a clinical and diagnostic study

As a rare multisystem congenital anomaly disorder, Cornelia de Lange syndrome (CdLS) is featured by delayed growth and development, distinct facial dimorphism, limb malformations and multiple organ defects. CdLS is a genetic syndrome affecting 1/10000-1/60000 neonates with unknown genetic basis. Delayed growth and development, hirsute, structural anomalies of the limbs and distinct facial dimorphism are considered as its main clinical characteristics. Introducing CdLS cases of different ethnic backgrounds could add distinctions to the phenotypic picture of the syndrome and be useful in diagnosis. Early diagnosis and decreased death rates are achievable through enhanced awareness on this syndrome. We present here a 45-day-old girl, as the first case of Cornelia in Golestan (Northern Iran), referred to our hospital with the symptoms as mentioned above. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved

Prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran

Asthma is the most common chronic disease among children, and its incidences are often imminent among elementary schoolchildren. This study aimed to examine the prevalence of asthma symptoms in Golestan schoolchildren aged 6–7 and 13–14 years in Northeast Iran. The prevalence rate was compared according to age group (aged 6–7 years vs. aged 13–14 years) and gender (male vs. female). In this cross-sectional study, 1706 Iranian schoolchildren aged 6–7 and 13–14 years in Golestan Province were enrolled. Participants completed questionnaires between February and July 2014. Asthma symptoms were assessed using the questionnaire of the International Study of Asthma and Allergies in Childhood protocol in Persian. The logistic regression model was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of the asthma symptoms for each of the gender and age groups. The prevalence rates of “current asthma” symptoms and “asthma ever” in all the children were estimated as 9.5% and 7.5%, respectively. The prevalence of asthma (“asthma ever” and “wheezing in the past 12 months”) in junior high schoolchildren (aged 13–14 years) is higher than that in elementary schoolchildren (aged 6–7 years) (P < 0.05). The prevalence of the severity of wheezing in girls is lower than that in boys (OR = 1.7, 95%CI = 1.06–2.96, P = 0.02). Asthma is still a major public health problem. This study shows that the prevalence of the asthma symptoms in boys is lower than that in girls in both age groups, and the severity of asthma in girls is higher than that in boys aged 13–14 years. © 2016 Higher Education Press and Springer-Verlag Berlin Heidelber

Magnetic Brane of Cubic Quasi-Topological Gravity in the Presence of Maxwell and Born-Infeld Electromagnetic Field

The main purpose of the present paper is analyzing magnetic brane solutions of cubic quasi-topological gravity in the presence of a linear electromagnetic Maxwell field and a nonlinear electromagnetic Born-Infeld field. We show that the mentioned magnetic solutions have no curvature singularity and also no horizons, but we observe that there is a conic geometry with a related deficit angle. We obtain the metric function and deficit angle and consider their behavior. We show that the attributes of our solution are dependent on cubic quasi-topological coefficient and the Gauss-Bonnet parameter.Comment: 15 pages and 8 figure

Surface Terms of Quartic Quasitopological Gravity and Thermodynamics of Nonlinear Charged Rotating Black Branes

As in the case of Einstein or Lovelock gravity, the action of quartic quasitopological gravity has not a well-defined variational principle. In this paper, we first introduce a surface term that makes the variation of quartic quasitopological gravity well defined. Second, we present the static charged solutions of quartic quasitopological gravity in the presence of a non linear electromagnetic field. One of the branch of these solutions presents a black brane with one or two horizons or a naked singularity depending on the charge and mass of the solution. The thermodynamic of these black branes are investigated through the use of the Gibbs free energy. In order to do this, we calculate the finite action by use of the counterterm method inspired by AdS/CFT correspondence. Introducing a Smarr-type formula, we also show that the conserved and thermodynamics quantities of these solutions satisfy the first law of thermodynamics. Finally, we present the charged rotating black branes in $(n+1)$ dimensions with $k\leq [n/2]$ rotation parameters and investigate their thermodynamics.Comment: 16 pages, Late

Bone mineral density in Iranian patients: Effects of age, sex, and body mass index

Introduction: Osteoporosis is a multifactorial skeletal disease that is characterized by reduced bone mineral density (BMD). BMD values de-pend on several factors such as age, sex and age at menopause. The purpose of this study was to determine the prevalence and changes in bone mineral density in Iranian patients. Meth-ods: Three hundred patients were selected through random sampling technique in 2009. BMD was assessed by Norland (Excell) technique at the lumbar and femoral neck. Weight and height were measured through standard methods. A thorough history was taken from each patient. The data was analyzed using SPSS software version 13.0. P-values less than 0.05 were con-sidered statistically significant. Results: From among the 300 studied patients, 86.6% were fe-male. their mean age was 52.7 years. Their av-erage body mass index (BMI) was 28.14 kg/m2. Mean T-Score at lumbar spine and femoral neck was −1.07 ± 1.19 and −1.75 ± 1.33 respectively. Mean BMD value at lumbar spine and femoral neck was 0.92 ± 0.19 and 0.77 ± 0.16 respectively. The prevalence of osteoporosis at lumbar spine and femoral neck was 33.7% and 16.7, respec-tively. There was a significant correlation be-tween age, BMI and BMD values (P-Value < 0.01). Correlation between gender and BMD value at the lumbar spine and femoral neck was not sig-nificant. Conclusion: This study shows that age- ing and low BMI are risk factors associated with bone loss. it is recommended to measure BMD and implement prevention programs for high- risk people. Keywords: Bone Mineral Density; Body Mass Index;Age; Gende

Black Holes in (Quartic) Quasitopological Gravity

We construct quartic quasitopological gravity, a theory of gravity containing terms quartic in the curvature that yields second order differential equations in the spherically symmetric case. Up to a term proportional to the quartic term in Lovelock gravity we find a unique solution for this quartic case, valid in any dimensionality larger than 4 except 8. This case is the highest degree of curvature coupling for which explicit black hole solutions can be constructed, and we obtain and analyze the various black hole solutions that emerge from the field equations in $(n+1)$ dimensions. We discuss the thermodynamics of these black holes and compute their entropy as a function of the horizon radius. We then make some general remarks about $K$-th order quasitopological gravity, and point out that the basic structure of the solutions will be the same in any dimensionality for general $K$ apart from particular cases.Comment: LaTex, 9 figures, 27 pages. A new section on holographic hydrodynamics is added. Introduction and concluding remarks have been revise

Association of the TCF7L2 rs12255372 (G/T) variant with type 2 diabetes mellitus in an Iranian population

In various populations worldwide, common variants of the TCF7L2 (Transcription factor 7-like 2) gene are associated with the risk of type 2 diabetes mellitus (T2DM). The aim was to investigate the association between rs12255372 (G/T) polymorphism in the TCF7L2 gene and T2DM in an Iranian population. 236 unrelated patients with T2DM, and 255 normoglycemic controls without diabetes were studied. The PCR-RFLP method was used for genotyping rs12255372 (G/T) polymorphism, and the SPSS version 18.0 for Windows for statistical analysis. The minor T allele of TCF7L2 rs12255372 was found to significantly increase the risk of T2DM, with an allelic odds ratio (OR) of 1.458 (95% CI 1.108-1.918, p = 0.007). A significant difference in TT genotype was observed between T2DM patients and normoglycemic controls (OR 2.038, 95% CI 1.147-3.623; p = 0.014). On assuming dominant and recessive models, ORs of 1.52 [95% CI (1.05-2.21) p = 0.026)] and 1.74 [95% CI (1.01-3.00) p = 0.043] were obtained, respectively, thereby implying that the co-dominant model would best fit the susceptible gene effect. This study further confirms the TCF7L2 gene as enhancing susceptibility to the development of T2DM. © 2012, Sociedade Brasileira de Genética